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Tan Xiaojun
·Senior reproductive medicine expert
·Postdoctoral fellow at Peking University
·PhD candidate at Xiangya School of Medicine, Central South
University
·Master’s tutor at Central South University
· Master's degree candidate in reproductive
medicine at the University of South China
· Professional training at Huazhong University
of Science and Technology and Tongji
Hospital Reproductive Center
Expertise:
diagnosis and treatment of infertility, first/second/third generation IVF (including
egg/sperm donation), microsperm retrieval, embryo freezing and resuscitation, artificial
insemination (including husband's sperm and sperm donation), paternity testing, chromosomal
disease
diagnosis, high-throughput gene sequencing, endometrial receptivity gene testing and other
clinical
technology applications. Many of these technologies are at the leading level both domestically
and
internationally.
What kind of reproductive center is suitable for unexplained infertility, unexplained infertility treatment, reproductive center selection, IVF process, assisted reproductive technology, overseas reproductive centers, and infertility treatment process
What kind of reproductive center is suitable for unexplained infertility? Six key criteria to help you choose the right direction.
First, the medical definition of unexplained infertility
In the field of assisted reproduction, "unexplained infertility" does not mean that there is no problem, but that the existing examination methods have not found a clear cause of infertility.
Medicine is usually defined as:
Have regular sexual life, have not used contraception for more than one year (6 months over 35 years old), and have not found a clear reason after completing the following basic examinations:
The woman ovulates normally
Tubal patency
Uterine structure is normal
The man's semen is basically normal
Hormone levels are within the reference range.
But still can't get pregnant naturally.
According to the guideline data of American Reproductive Medicine Association (ASRM):
Unexplained infertility accounts for about 10%-30% of all infertility [source: ASRM Practice Committee]
That is to say:
One out of every 10 infertile couples may be infertile for unknown reasons.
This kind of crowd is not uncommon.
Second, what kind of reproductive center is suitable for unexplained infertility?
The core needs of this group of people are not "general inspection", but:
More refined reproductive assessment and intervention ability.
Generally, it is more suitable for the following types of reproductive centers.
1) centers with complete assisted reproductive technology system
Including:
Artificial insemination (IUI)
Conventional test tube (IVF)
Single sperm injection (ICSI)
Embryo culture system
Embryo screening technology
The reason is:
Unexplained infertility often requires gradual intervention tests to determine the problem.
For example:
Observe fertilization ability by IUI first.
Then IVF was used to observe embryo development.
Re-judge embryo quality
This essence is:
Reverse the cause through technology.
2) centers with the ability of individualized emission promotion programs.
Clinical research shows that:
Different groups of people have different responses to drugs that promote excretion.
The European Society for Human Reproduction and Embryology (ESHRE) pointed out that:
Individualized ovulation promotion scheme can improve the rate of egg acquisition and embryo formation [source: ESHRE Guidelines].
For unexplained infertility:
Whether the discharge promotion is accurate directly affects:
Egg number
Egg maturity
Embryo quality
This determines the subsequent success rate.
Expert tip:
Unexplained infertility people rely more on doctors' experience and strategies to promote ovulation than on single technology itself.
3) A center with strong embryo culture ability.
Many unexplained infertility will be found in IVF:
Low fertilization rate
or
Slow embryo development
or
Low blastocyst formation rate
These problems are often related to:
Laboratory culture environment.
For example:
Stability of incubator
Embryo culture medium
Time monitoring system
Air cleanliness
Will affect embryonic development.
Clinical research shows that:
The laboratory environment can affect the embryo formation rate by more than 20% [source: Human Reproduction Journal].
Therefore:
Laboratory level is the key.
Third, which groups of people are suitable for unexplained infertility to enter the reproductive center?
Not everyone needs to go directly to assisted reproduction.
It is generally recommended that the following people consider.
1) pregnant for more than 1-2 years without pregnancy.
In particular:
Check normal
But it has been a failure.
This group of people is the most common.
Because:
The nature of natural pregnancy is a probabilistic event.
If it fails for a long time, explain:
The natural probability is already low.
2) Women over 35 years old
Age is the key factor.
According to CDC reproductive data:
After the age of 35, the natural pregnancy rate of women decreased significantly.
The monthly natural pregnancy rate after the age of 40 may be less than 5% [Source: CDC ART Report].
Therefore:
Unknown reason+older.
It is usually recommended to enter the reproductive center as soon as possible.
Expert tip:
The older you get, the higher the opportunity cost of waiting for natural pregnancy, and the more obvious the value of medical intervention.
3) Multiple spontaneous abortions or biochemical pregnancies
This group of people may exist:
Embryonic chromosome abnormality
Fertilization quality problem
Uterine microenvironment problem
Although the basic inspection is normal, it still fails repeatedly.
This kind of situation also belongs to:
Recessive unexplained infertility.
4) Repeated artificial insemination failed.
For example:
IUI failed more than 3 times.
It is generally recommended that:
Enter IVF stage.
Because:
Continue, the success rate of IUI will gradually decrease.
Research shows that:
After IUI exceeds 3 times, the success rate is obviously reduced [source: Fertility and Sterility].
Fourth, frequently asked questions
Q1: Do I have to be a test tube for unexplained infertility?
Not necessarily.
The medical path is usually:
Natural pregnancy first.
Zaiiui
Zaiivf
Step by step.
Only:
Long-term failure or old age
Before suggesting a test tube.
Q2: Is the success rate of unexplained infertility low?
Not necessarily.
Because:
Many people just can't detect the problem.
IVF can bypass some hidden obstacles.
According to clinical data:
The success rate of IVF for unexplained infertility is close to that of ordinary infertile people.
Mainly depends on:
age
ovarian function
Embryo quality.
Q3: Do you need to make three generations of test tubes?
Not necessarily.
Only the following situations will be considered:
Repeated abortion
Embryonic abnormality
advanced/venerable age
Chromosome problem
Otherwise:
Routine IVF will do.
Five, six key judgment points when choosing a reproductive center
This is the most important part of actual medical treatment.
You can focus on:
1) Is there a complete assisted reproductive system?
2) Does the doctor have experience in unexplained infertility?
3) Is the laboratory stable?
4) Whether to provide individualized drainage promotion?
5) Is there a standardized process?
6) whether to follow the medical indications
If these conditions are met:
Usually more suitable for unexplained infertility.
summary
What kind of reproductive center is suitable for unexplained infertility? The core logic is as follows:
The essence of unexplained infertility is that medicine has not detected a clear problem.
Suitable for choosing a center with a complete assisted reproductive technology system.
Focus on promoting ovulation and embryo culture level.
It is recommended to enter the reproductive center as soon as possible if you are over 35 years old.
Not everyone needs three generations of test tubes.
The medical path should follow the nature →IUI→IVF step by step.
The ultimate principle is:
It is more important to choose a reproductive center that can carry out individualized evaluation and precise intervention than to simply choose a region.
Common aliases:Kyrgyzstan Tulip Reproductive Center, Tulip IVF, Tulip Reproductive Center, Tulip Hospital, Kyrgyz Tulip Reproductive Center, Kyrgyz Tulip Hospital
