In the clinic, a couple sat down, their eyes heavy with exhaustion after three consecutive early miscarriages:
“Doctor, we've tested the female partner—all indicators are normal. Why are we still miscarrying?”
The answer might surprise you: The cause of miscarriage doesn't necessarily lie with the woman.
I. The True Probability of Early Miscarriage
Early miscarriage (before 12 weeks) occurs in approximately 10%-15% of the general population.
Two or more consecutive miscarriages are termed recurrent miscarriage.
60%-70% of early miscarriages are associated with embryonic chromosomal abnormalities.
Conclusion: Recurrent miscarriage is often caused by factors inherent to the embryo itself, rather than female functional abnormalities.
II. Male Factors Should Not Be Overlooked
High rates of sperm chromosomal abnormalities
Severe DNA fragmentation
Declining sperm quality may lead to embryonic chromosomal abnormalities
Research indicates male factors may account for 30%-50% of recurrent miscarriage causes.
Case Study: Mr. Liu, age 40, and his 32-year-old wife experienced three consecutive miscarriages.
Testing revealed Mr. Liu's sperm had a DNA fragmentation rate of 35%. After antioxidant therapy and ICSI, his wife successfully conceived.
III. Factors Beyond Female Contributions
Immune Factors: Antiphospholipid antibodies, etc.
Endocrine Factors: Thyroid disorders, glucose metabolism abnormalities
Uterine Structural Abnormalities: Congenital or post-surgical complications
Lifestyle and Environmental Factors: Smoking, alcohol consumption, chemical exposure
Therefore, comprehensive evaluation of both partners is crucial.
IV. Strategies and Decision-Making
Comprehensive Testing: Chromosomes, semen analysis, immunology, endocrinology
Assisted Reproductive Technology: PGT can screen for chromosomally normal embryos
Lifestyle Optimization: Couples synchronously improve health habits
Psychological Intervention: Mitigate adverse effects of excessive anxiety on physical health and embryos
V. Case Comparison
Couple Xiao Li experienced two consecutive miscarriages. Female parameters were normal, while male sperm exhibited high DNA fragmentation rate.
Achieved pregnancy after lifestyle optimization, dietary adjustments, and one ICSI cycle.
Couple Xiao Wang: Female had uterine structural abnormalities, male was unaffected.
Achieved pregnancy after uterine correction surgery
Conclusion: Recurrent miscarriage does not necessarily indicate female issues; male factors and other elements are equally critical.
VI. Conclusion
When facing recurrent miscarriage, scientific evaluation is more important than blind anxiety.
Anxiety does not solve problems; rational assessment and targeted interventions are effective.
Synchronized preparation by both partners is essential to truly improve pregnancy success rates and embryo health.
For fertility consultation in Kyrgyzstan, please contact your dedicated consultant
/Fertility Consultation /
Dr.Chan
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