In clinical counseling for assisted reproduction, many elderly families preparing for pregnancy face a common dilemma: why do they repeatedly experience fetal arrest or prompt "embryonic chromosomal abnormalities" in blastocyst screening even though both spouses' chromosome karyotyping results are normal? This not only undermines confidence in preparing for pregnancy, but also increases time and economic costs.

In fact, the incidence of chromosomal abnormalities in embryos is positively correlated with age. When females exceed the age of 35 and males exceed the age of 40, the probability of reproductive cell errors during meiosis significantly increases. In order to assist everyone in scientifically addressing this challenge, the Tulip International Reproductive Center has conducted an in-depth analysis of the pathological mechanisms behind this phenomenon.

Normal somatic cells in the human body contain 46 chromosomes. The formation of an embryo requires 23 chromosomes each from the sperm and egg, and precise pairing. This process relies on two meiotic divisions of germ cells. Once there is a deviation in the division process, resulting in an increase or decrease in chromosome number (non diploid) or structural damage, abnormal embryos will be formed.

In response to this complex biological phenomenon, Dr. Chen Yinuo, founder of Tulip International Reproductive Center, provided a professional interpretation from a clinical medical perspective:

In the clinical practice of Tulip International Reproductive Center, we must use third-generation in vitro fertilization technology (PGT) to remove abnormal embryos. But more importantly, understanding its source. Many patients mistakenly believe that if their parents have normal chromosomes, the embryo must be normal, which is a misunderstanding of genetics. The decline of mitochondrial function in oocytes of elderly women is the core cause. Mitochondria are the main site for the production of adenosine triphosphate (ATP) within cells, providing energy for chromosome separation. As age increases, the energy produced by mitochondria in the egg becomes insufficient, leading to abnormal spindle assembly during meiosis and the inability of chromosomes to accurately separate to the poles, resulting in the production of aneuploid eggs. In addition, excessive levels of oxidative stress in the body can directly damage DNA repair mechanisms, further increasing the risk of replication errors. Therefore, in our clinical treatment in Kyrgyzstan, we place great emphasis on genetic screening before transplantation and mitochondrial function regulation during the preconception period. ”

By understanding the core reasons, we can intervene more targetedly. Embryonic chromosomal abnormalities are usually divided into aneuploid abnormalities and structural abnormalities.

Non diploid abnormalities (quantity issue): accounting for about 60% -70% of embryonic abnormalities, mainly dominated by female factors. In addition to the decline in mitochondrial function mentioned by Dean Chen Yinuo, the endocrine environment (such as abnormal LH secretion) is also an important influencing factor.

Chromosomal structural abnormalities (structural problems): such as chromosome duplication, inversion, or translocation, which are more closely associated with male factors. Smoking, alcohol abuse, and high-pressure environments can lead to an increase in sperm DNA fragmentation rate, which in turn affects the genetic stability of embryos.

To reduce this risk, Tulip International Reproductive Center recommends that elderly families preparing for pregnancy undergo scientific adjustments from the following four dimensions:

Firstly, it is necessary to improve the energy metabolism of reproductive cells, supplement nutrients such as coenzyme Q10 appropriately, and enhance mitochondrial efficiency; Secondly, establish an antioxidant defense system by consuming antioxidants such as vitamin C and E to reduce the damage of reactive oxygen species to DNA; The third is to maintain endocrine stability, avoid long-term staying up late and high sugar diets, and maintain hormonal balance; Finally, it is important to strictly avoid environmental toxins and stay away from contact with heavy metals and organic solvents.

Preparing for pregnancy at an advanced age is a race against time, but it is not without solutions. Through scientific etiological analysis and targeted regulation, combined with the mature assisted reproductive technology of Tulip International Reproductive Center, we can still effectively reduce the probability of chromosomal abnormalities in embryos and create favorable conditions for the arrival of healthy life.

For fertility consultation in Kyrgyzstan, please contact your dedicated consultant

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