For Ms. Xie, who is 40 years old, she has walked the path of "becoming a mother" for a full 7 years, with every step accompanied by the rise of hope and the fall of despair.
In 2016, during her first pregnancy, she experienced fetal arrest in her 40s.
In 2018, during her second pregnancy, she experienced another miscarriage, and this time, the diagnosis stated that she had a complete molar pregnancy
This is not an ordinary miscarriage.
Complete molar pregnancy is an abnormal and pathological pregnancy. Simply put, a serious genetic error occurs during fertilization: the nucleus of the egg cell (carrying the mother's chromosomes) is missing or inactivated, and one or two sperm enter, causing their chromosomes to self replicate, resulting in the embryo containing only paternal genetic material.
Such embryos cannot develop into normal fetuses, but instead form clusters of vesicular nourishing cell tissues, which not only fail to survive but also pose a potential risk of developing invasive molar pregnancy or choriocarcinoma, requiring strict long-term medical follow-up.
However, the nightmare did not end there. In 2019 and 2021, Ms. Xie experienced two more pregnancies, and the diagnosis was still 'complete molar pregnancy'.
Seven years, four pregnancies, four curettage surgeries, and four identical diagnoses. Repeated hopes and despair almost completely destroyed her confidence.
Why is it always me? Do I really not have the opportunity to be a mother anymore
With this last glimmer of almost hopeless hope, Ms. Xie and her husband arrived at the Kyrgyzstan Tulip International Reproductive Center.
Step 1: Uncover the culprit behind repeated failures
At Tulip, our expert team arranged a systematic fertility assessment for Ms. and Mrs. Xie, revealing the root cause of the problem.
【1】 Female evaluation:
At the age of 40, she has already entered the ranks of advanced childbearing.
B-ultrasound examination showed that her bilateral ovarian antral follicle count (AFC) was only 6, and her AMH value was also low, which clearly indicates "ovarian reserve dysfunction (DOR)".
This means that obtaining a sufficient number of eggs will be a huge challenge in subsequent IVF treatments.
【2】 Male evaluation:
Given the rare history of recurrent "complete molar pregnancy" in the female partner, the investigation of male factors is equally crucial.
Although the husband's routine semen analysis indicators (concentration, vitality, etc.) are within the normal range, our experts insist on conducting deeper sperm DNA fragmentation rate (DFI) testing.
The results showed a mild increase in DFI, indicating a certain degree of damage to the genetic integrity of sperm, which may be a potential factor leading to abnormal fertilization and decreased embryonic development potential.
【3】 Comprehensive diagnosis and strategy formulation:
Based on the situation of both parties, the clinical diagnosis is very clear: recurrent miscarriage (highly suspected of embryonic chromosomal abnormalities), ovarian reserve dysfunction (DOR), and mild male factors.
Our expert team pointed out that Ms. Xie's repeated experience of 'complete molar pregnancy' is essentially due to severe chromosomal abnormalities in the fertilized egg. The only way to break this curse is through third-generation in vitro fertilization technology (PGT-A), which involves genetic screening before embryo transfer to ensure that the implanted embryo has completely normal chromosomes.
The treatment plan has been determined as: ICSI (intracytoplasmic sperm injection)+blastocyst culture+PGT-A (pre implantation aneuploidy genetic testing).
Step 2: Counter Strike Under Precision Medicine
The first attempt at ovulation induction was not ideal.
Due to poor ovarian reserve function, only 3 eggs were obtained under conventional antagonist regimens, and no detectable blastocysts were ultimately formed.
However, the expert team of Tulip did not give up, but immediately organized a multidisciplinary consultation to deeply review and optimize the plan.
The second ovulation induction was carried out using an improved luteal phase ovulation induction program, which is a personalized strategy for low response populations. This time, the effect significantly improved - ultimately successfully obtaining 6 mature eggs!
These 6 precious eggs were fertilized using ICSI technology and carefully cultured in our top embryology laboratory. In the end, three of them developed to the blastocyst stage! These 3 blastocysts were immediately biopsied, frozen, and sent to a genetic testing center for PGT-A screening.
The days of waiting for results are filled with torment every day.
In the end, the report brought decisive good news: two embryos were diploid with completely normal chromosomes, making them the best choice for priority transplantation.
After thorough preparation of Ms. Xie's endometrium, the doctor transplanted one of her diploid blastocysts.
The goddess of luck has finally descended. 14 days after transplantation, the blood hCG test result was positive!
During the follow-up ultrasound examination, Ms. Xie successfully observed the strong fetal heartbeat that they had been waiting for for 7 years.
At present, Ms. Xie's various prenatal examination indicators are stable and normal. The haze of 7 years has finally been dispelled, and advanced medical technology and unremitting perseverance have brought the most precious dawn of life to this family that has gone through hardships.
(This article is adapted from a real customer case, and some details have been anonymized to protect privacy.)
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